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      LF3研究進(jìn)展
      
                
      
                發(fā)布日期：2017-10-30                                                  瀏覽次數(shù)：0
                
      

      核心提示：a href=https://www.medchemexpress.com/LF3.htmlLF3/a產(chǎn)品描述：LF3 is an antagonist of the b-Catenin/TCF4/b interaction wi
                                      
      
    
    
        
      
            <a   href="https://www.medchemexpress.com/LF3.html">LF3</a>產(chǎn)品描述：LF3   is an antagonist of the <b>β-Catenin/TCF4</b> interaction with   antitumor activity; has an <b>IC<sub>50</sub></b> of   1.65 μM.
      
            
      
            IC50 & Target: IC50: 1.65 μM (β-Catenin/TCF4, AlphaScreen), 1.82 μM   (β-Catenin/TCF4, ELISA)<sup>[1]</sup>
      
            
      
            <i><b>In Vitro:</b></i> LF3 inhibits Wnt/β-catenin   signals in cells with exogenous reporters and in colon cancer cells with   endogenously high Wnt activity. LF3 also suppresses features of cancer cells   related to Wnt signaling, including high cell motility, cell-cycle   progression, and the overexpression of Wnt target genes. However, LF3 does   not cause cell death or interfere with cadherin-mediated cell-cell adhesion.   Remarkably, the self-renewal capacity of cancer stem cells is blocked by LF3   in concentration-dependent manners<sup>[1]</sup>.
      
            
      
            <i><b>In Vivo:</b></i> LF3 reduces tumor growth and   induces differentiation in a mouse xenograft model of colon cancer. Tumor   growth is significantly reduced when mice with GFP<sup>high</sup>   cells are treated with<br><br>
      
            <br>
      
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            已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a   href="http://www.medchemexpress.cn/lf3.html">www.medchemexpress.cn/lf3.html</a><br><br></span><img   style="width: 600.0px;height: 310.0px;" 
      
            
      
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