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      Iberin研究進(jìn)展
      
                
      
                發(fā)布日期：2017-10-30                                                  瀏覽次數(shù)：0
                
      

      核心提示：a href=https://www.medchemexpress.com/Iberin.htmlIberin/a產(chǎn)品描述：Iberin, a sulfoxide analogue of sulforaphane, is a na
                                      
      
    
    
        
      
            <a   href="https://www.medchemexpress.com/Iberin.html">Iberin</a>產(chǎn)品描述：Iberin,   a sulfoxide analogue of sulforaphane, is a naturally occurring member of   isothiocyanate family. It inhibits cell survival with an   <b>IC<sub>50</sub></b> of 2.3 μM in HL60 cell.
      
            
      
            IC50 & Target: IC50: 2.3 μM (HL60 cell)<sup>[1]</sup>
      
            
      
            <i><b>In Vitro:</b></i>  Iberin inhibits the growth of neuroblastoma   cells in a dose- and time-dependent manner. The iberin-induced cell cycle   arrest in neuroblastoma cells is associated with inhibition of expression of   cyclin-dependent kinase Cdk2, Cdk4, and Cdk6 proteins. There is an increase   in apoptotic cell death in iberin treated cells as compared with control   cells. The iberin-induced apoptosis is found to be associated with activation   of caspase-9, caspase-3, and PARP<sup>[2]</sup>. Iberin inhibits   growth of human glioblastoma cells in cell proliferation assays, enhances   cytotoxicity, and induces apoptosis by activation of caspase-3 and   caspase-9<sup>[3]</sup>. 
      
            
      
            <i><b>In Vivo:</b></i> Iberin is tested in an   <i>in vivo</i> foreign-body infe<br><br>
      
            <br>
      
            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動(dòng)劑、API及化合物庫(kù)，總部位于美國(guó)新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理，營(yíng)銷網(wǎng)點(diǎn)遍及全球20多個(gè)國(guó)家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商，   產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個(gè)熱門研究領(lǐng)域，PI3K、MAPK等近千個(gè)細(xì)分靶點(diǎn)，超過4000個(gè)活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫(kù)，同時(shí)提供從毫克到千克的專業(yè)定制合成服務(wù)。</span>
      
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            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">大量產(chǎn)品提供免費(fèi)試用裝；</span>
      
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            已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫(kù)。</span><br><br>產(chǎn)品鏈接：<a   href="http://www.medchemexpress.cn/iberin.html">www.medchemexpress.cn/iberin.html</a><br><br></span><img   style="width: 600.0px;height: 310.0px;" 
      
            
      
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