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      Gestrinone研究進展
      
                
      
                發(fā)布日期：2017-10-30                                                  瀏覽次數(shù)：0
                
      

      核心提示：a href=https://www.medchemexpress.com/Gestrinone.htmlGestrinone/a產(chǎn)品描述：Gestrinone (R2323) is a synthetic steroid hor
                                      
      
    
    
        
      
            <a   href="https://www.medchemexpress.com/Gestrinone.html">Gestrinone</a>產(chǎn)品描述：Gestrinone   (R2323) is a synthetic steroid hormone used to treat endometriosis. It   inhibits leiomyoma cells with an <b>IC<sub>50</sub></b>   of 43.67 μM.
      
            
      
            IC50 & Target: IC50: 43.67 μM (leiomyoma   cells)<sup>[2]</sup>
      
            
      
            <i><b>In Vitro:</b></i> Gestrinone binds to   endometrial receptors for estrogen, progesterone and androgen, occupies all   specific binding sites of steroids in the steroid target cells despite the   presence of endogenous steroids<sup>[1]</sup>. Gestrinone   exhibits stronger inhibitory effects on the growth of leiomyoma cells at 60 h   than that at 20 and 40 h. Leiomyoma cells appears less dense, the cytoplasm   is atrophic, the intercellular connections dwindled and nuclear aggregations   are observed with more than 10 μM gestrinone treatment. Gestrinone treatment   reduces the relative mRNA levels of estrogen α in a concentration dependent   manner at concentrations of 0.1-3.0 μM<sup>[2]</sup>.
      
            
      
            <i><b>In Vivo:</b></i> The estrogen-sensitive   endpoints, vaginal keratinization and uterine <br><br>
      
            <br>
      
            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理，營銷網(wǎng)點遍及全球20多個國家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商，   產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個熱門研究領(lǐng)域，PI3K、MAPK等近千個細(xì)分靶點，超過4000個活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時提供從毫克到千克的專業(yè)定制合成服務(wù)。</span>
      
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            已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a   href="http://www.medchemexpress.cn/gestrinone.html">www.medchemexpress.cn/gestrinone.html</a><br><br></span><img   style="width: 600.0px;height: 310.0px;" 
      
            
      
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