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      ASK1-IN-1研究進展
      
                
      
                發(fā)布日期：2017-10-27                                                  瀏覽次數：0
                
      

      核心提示：a href=https://www.medchemexpress.com/ASK1-IN-1.htmlASK1-IN-1/a產品描述：ASK1-IN-1 is an apoptosis signal regulating kin
                                      
      
    
    
        
      
            <a   href="https://www.medchemexpress.com/ASK1-IN-1.html">ASK1-IN-1</a>產品描述：ASK1-IN-1   is an apoptosis signal regulating kinase 1 (<b>ASK1</b>)   inhibitor extracted from patent WO2016025474A1, Compound 4.
      
            
      
            IC50 & Target: ASK1<sup>[1]</sup>
      
            
      
            <i><b>In Vivo:</b></i> ASK1-IN-1 dose-dependently   decreases pulmonary arterial pressure and right ventricular (RV) hypertrophy   in an in vivo model of pulmonary hypertension (PH). ASKl inhibition reduces   hallmarks of pulmonary vascular disease including and not limited to reduce   pulmonary vascular resistance (PVR), improve pulmonary pressure, decreased   pulmonary vascular remodeling, improved vascular function, decrease maladaptive   RV hypertrophy, and improve RV function. Inhibition of ASKl signaling may   slow, prevent, and/or reverse pathological changes associated with PH. Plasma   levels of B-type natriuretic peptide (BNP) are reduced by both doses of   ASK1-IN-1: 0.1+0.05 for 0.1% and 0.1±0.1 ng/mL for 0.2%. Su/Hx rats treated   with 0.1 % or 0.2% ASK1-IN-1 has a decreased number of completely   muscularized arterioles (35.6% and 3<br><br>
      
            <br>
      
            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設有歐洲區(qū)子公司和亞洲區(qū)總代理，營銷網點遍及全球20多個國家地區(qū)。MCE經過多年努力已成為全球生物活性小分子領域的一流供應商，   產品涵蓋癌癥、神經科學、抗感染、表觀遺傳學等20個熱門研究領域，PI3K、MAPK等近千個細分靶點，超過4000個活性小分子化合物現貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時提供從毫克到千克的專業(yè)定制合成服務。</span>
      
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            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">MCE   對每批產品都進行嚴格的LCMS和NMR檢驗，其產品已被全球近萬名客戶廣泛使用并發(fā)表大量文章、專利；</span>
      
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            已為全球多個知名企業(yè)、院校構建各種定制型化合物庫。</span><br><br>產品鏈接：<a   href="http://www.medchemexpress.cn/ask1-in-1.html">www.medchemexpress.cn/ask1-in-1.html</a><br><br></span><img   style="width: 600.0px;height: 310.0px;" 
      
            
      
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