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      MK-0591
      
                
      
                發(fā)布日期：2017-10-26                                                  瀏覽次數(shù)：0
                
      

      核心提示：a href=https://www.medchemexpress.com/MK-0591.htmlMK-0591/a產(chǎn)品描述：MK-0591 is a selective and specific 5-Lipoxygenase-
                                      
      
    
    
        
      
            <a   href="https://www.medchemexpress.com/MK-0591.html">MK-0591</a>產(chǎn)品描述：MK-0591   is a selective and specific 5-Lipoxygenase-activating protein (FLAP)   inhibitor with an IC50 value of 1.6 nM in a FLAP binding assay. 
      
            
      
            IC50 value: 1.6 nM [1]
      
            
      
            Target: FLAP
      
            
      
            in vitro: MK-0591 is a potent inhibitor of leukotriene (LT) biosynthesis in   intact human and elicited rat polymorphonuclear leukocytes (PMNLs) (IC50   values 3.1 and 6.1 nM, respectively) and in human, squirrel monkey, and rat   whole blood (IC50 values 510, 69, and 9 nM, respectively). MK-0591 had no   effect on rat 5-lipoxygenase. MK-0591 has a high affinity for 5-lipoxygenase   activating protein (FLAP) as evidenced by an IC50 value of 1.6 nM in a FLAP   binding assay and inhibition of the photoaffinity labelling of FLAP by two   different photoaffinity ligands. Inhibition of activation of 5-lipoxygenase   was shown through inhibition of the translocation of the enzyme from the   cytosol to the membrane in human PMNLs [1].
      
            
      
            in vivo: MK-0591 was a potent inhibitor of LT biosynthesis in vivo, first,   following ex vivo chal<br><br>
      
            <br>
      
            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動(dòng)劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理，營銷網(wǎng)點(diǎn)遍及全球20多個(gè)國家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商，   產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個(gè)熱門研究領(lǐng)域，PI3K、MAPK等近千個(gè)細(xì)分靶點(diǎn)，超過4000個(gè)活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時(shí)提供從毫克到千克的專業(yè)定制合成服務(wù)。</span>
      
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            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">MCE   對(duì)每批產(chǎn)品都進(jìn)行嚴(yán)格的LCMS和NMR檢驗(yàn)，其產(chǎn)品已被全球近萬名客戶廣泛使用并發(fā)表大量文章、專利；</span>
      
            <br style="color: rgb(62,62,62);font-family: "Helvetica   Neue" , Helvetica , Arial , sans-serif;font-size:   11.818182px;line-height: 22.0px;background-color:   rgb(251,251,251);">
      
            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">MCE   定期增加各領(lǐng)域熱門抑制劑、激動(dòng)劑，不斷擴(kuò)增已有化合物庫，以滿足最新的科研需求；</span>
      
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            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">大量產(chǎn)品提供免費(fèi)試用裝；</span>
      
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            已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a   href="http://www.medchemexpress.cn/mk-0591.html">www.medchemexpress.cn/mk-0591.html</a><br><br></span><img   style="width: 600.0px;height: 310.0px;" 
      
            
      
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