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      DREADD agonist 21
      
                
      
                發(fā)布日期：2017-10-26                                                  瀏覽次數(shù)：0
                
      

      核心提示：a href=https://www.medchemexpress.com/DREADD-agonist-21.htmlDREADD agonist 21/a產(chǎn)品描述：DREADD agonist 21 is a potent h
                                      
      
    
    
        
      
            <a   href="https://www.medchemexpress.com/DREADD-agonist-21.html">DREADD   agonist 21</a>產(chǎn)品描述：DREADD agonist 21 is a potent human muscarinic   acetylcholine M3 receptors (<b>hM3Dq</b>)   agonist(<b>EC<sub>50</sub></b>=1.7 nM). 
      
            
      
            IC50 & Target: EC50: 1.7 nM   (hM3Dq)<sup>[1]</sup><br/>Ki: 6 nM (H1 histamine receptor),   66 nM (5HT2A serotonin receptor 5HT2A), 170 nM (5HT2C serotonin receptor),   280 nM (α1A adrenergic receptor)<sup>[1]</sup>
      
            
      
            <i><b>In Vitro:</b></i> DREADD agonist 21 is a   potent human muscarinic acetylcholine M3 receptors (hM3Dq) agonist   (EC<sub>50</sub>=1.7 nM) and does not activate human M3 receptor   (hM3). In addition to being inactive at hM3, DREADD agonist 21, a potent full   agonist of hM3Dq (EC<sub>50</sub>=1.7 nM), is only 3.5-fold   selective for hM3Dq over H1, 40-fold selective over 5HT2A, 100-fold selective   over 5HT2C, and 165-fold selective over α1A. DREADD agonist 21 shows high   binding affinities to 5HT2A and 5HT2C serotonin receptor, α1A adrenergic   receptor, and H1 histamine receptor with K<sub>i</sub> values of   66, 170, 280, and 6 nM, respectively<sup>[1]</sup><br><br>
      
            <br>
      
            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設有歐洲區(qū)子公司和亞洲區(qū)總代理，營銷網(wǎng)點遍及全球20多個國家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領域的一流供應商，   產(chǎn)品涵蓋癌癥、神經(jīng)科學、抗感染、表觀遺傳學等20個熱門研究領域，PI3K、MAPK等近千個細分靶點，超過4000個活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時提供從毫克到千克的專業(yè)定制合成服務。</span>
      
            <br style="color: rgb(62,62,62);font-family: "Helvetica   Neue" , Helvetica , Arial , sans-serif;font-size:   11.818182px;line-height: 22.0px;background-color:   rgb(251,251,251);">
      
            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">MCE 對每批產(chǎn)品都進行嚴格的LCMS和NMR檢驗，其產(chǎn)品已被全球近萬名客戶廣泛使用并發(fā)表大量文章、專利；</span>
      
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            <span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family:   "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size:   11.818182px;background-color:   rgb(251,251,251);">大量產(chǎn)品提供免費試用裝；</span>
      
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            已為全球多個知名企業(yè)、院校構建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a   href="http://www.medchemexpress.cn/dreadd-agonist-21.html">www.medchemexpress.cn/dreadd-agonist-21.html</a><br><br></span><img   style="width: 600.0px;height: 310.0px;" 
      
            
      
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