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      Ro 41-1049 (hydrochloride)
      
                
      
                發(fā)布日期：2017-10-26                                                  瀏覽次數(shù)：0
                
      

      核心提示：a href=https://www.medchemexpress.com/Ro-41-1049-hydrochloride.htmlRo 41-1049 (hydrochloride)/a產(chǎn)品描述：Ro 41-1049 hydr
                                      
      
    
    
        
      
            <a   href="https://www.medchemexpress.com/Ro-41-1049-hydrochloride.html">Ro   41-1049 (hydrochloride)</a>產(chǎn)品描述：Ro 41-1049 hydrochloride is a   selective, reversible, orally-active MAO-A inhibitor.
      
            
      
            Target: MAO
      
            
      
            in vivo: Ro 41-1049 is an inhibitor of the enzyme monoamine oxidase type A   (MAO-A) to rats and monitored extracellular catecholamine levels in the   corpus striatum before and after the intraperitoneal (IP) administration of a   bolus of L-dopa. Acute administration of Ro 41-1049 (1-50 mg/kg IP) produced   a dose-dependent decrease in basal levels of the dopamine metabolites   3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) and an   increase in basal levels of dopamine. In rats treated with Ro 41-1049 (20   mg/kg IP), L-dopa administration (100 mg/kg IP) produced a greater increase   in striatal levels of dopamine than it did in controls, while DOPAC and HVA   formation was attenuated. We conclude that inhibition of central MAO-A   activity promotes synaptic accumulation of dopamine following administration   of pharmacological doses of L-dopa.<br><br>
      
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            已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a   href="http://www.medchemexpress.cn/ro-41-1049-hydrochloride.html">www.medchemexpress.cn/ro-41-1049-hydrochloride.html</a><br><br></span><img   style="width: 600.0px;height: 310.0px;" 
      
            
      
            src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"   
      
            
      
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