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      Calcipotriol (monohydrate)
      
                
      
                發(fā)布日期：2017-10-26                                                  瀏覽次數(shù)：0
                
      

      核心提示：a href=https://www.medchemexpress.com/Calcipotriol-monohydrate.htmlCalcipotriol (monohydrate)/a產(chǎn)品描述：Calcipotriol mo
                                      
      
    
    
        
      
            <a   href="https://www.medchemexpress.com/Calcipotriol-monohydrate.html">Calcipotriol   (monohydrate)</a>產(chǎn)品描述：Calcipotriol monohydrate is a synthetic VitD3   analogue with a high affinity for the <b>vitamin D</b> receptor.
      
            
      
            IC50 & Target: vitamin D receptor<sup>[1]</sup>
      
            
      
            <i><b>In Vitro:</b></i> When NHEK cells are not   stimulated with IL-17A or IL-22, Calcipotriol slightly enhances (0.2 nM) IL-8   mRNA expression or has no effect (2-20 nM). The addition of IL-17A and IL-22   markedly increased the mRNA expression of IL-8, confirming our previous   study. This enhanced IL-8 mRNA expression is suppressed by Calcipotriol at 2,   20 and 40 nM in a dose dependent manner<sup>[1]</sup>. Treatment   of natural killer (NK) cells with drugs modulates their expression of NK   cytotoxicity receptors or KIR. Human NK cells are pre-treated with 100, 10 or   1 ng/mL of 1,25(OH)<sub>2</sub>D<sub>3</sub>,   Calcipotriol or FTY720 for 4 h. All three concentrations of   1,25(OH)<sub>2</sub>D<sub>3</sub>, Calcipotriol and   FTY720 significantly up-regulate the expression of NKp30 on the surface of NK   cells after 4 h incubation<sup>[2<br><br>
      
            <br>
      
            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動(dòng)劑、API及化合物庫(kù)，總部位于美國(guó)新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理，營(yíng)銷網(wǎng)點(diǎn)遍及全球20多個(gè)國(guó)家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商，   產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個(gè)熱門研究領(lǐng)域，PI3K、MAPK等近千個(gè)細(xì)分靶點(diǎn)，超過4000個(gè)活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫(kù)，同時(shí)提供從毫克到千克的專業(yè)定制合成服務(wù)。</span>
      
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            <span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family:   "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size:   11.818182px;background-color:   rgb(251,251,251);">大量產(chǎn)品提供免費(fèi)試用裝；</span>
      
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            已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫(kù)。</span><br><br>產(chǎn)品鏈接：<a   href="http://www.medchemexpress.cn/calcipotriol-monohydrate.html">www.medchemexpress.cn/calcipotriol-monohydrate.html</a><br><br></span><img   style="width: 600.0px;height: 310.0px;" 
      
            
      
            src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"   
      
            
      
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