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      SKF-96365 (hydrochloride)
      
                
      
                發(fā)布日期：2017-10-26                                                  瀏覽次數(shù)：0
                
      

      核心提示：a href=https://www.medchemexpress.com/SKF-96365-hydrochloride.htmlSKF-96365 (hydrochloride)/a產(chǎn)品描述：SKF-96365 hydroch
                                      
      
    
    
        
      
            <a   href="https://www.medchemexpress.com/SKF-96365-hydrochloride.html">SKF-96365   (hydrochloride)</a>產(chǎn)品描述：SKF-96365 hydrochloride, an   <b>SOCE</b> inhibitor, exhibits potent anti-neoplastic activity   by inducing cell-cycle arrest and apoptosis in colorectal cancer cells.
      
            
      
            
      
            <i><b>In Vitro:</b></i> SKF-96365 exhibits potent   anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in   colorectal cancer cells. SKF-96365 inhibits hERG current in a   concentration-dependent manner<sup>[1]</sup>. SKF-96365 can   induces cytoprotective autophagy to delay apoptosis by preventing the release   of cytochrome c (cyt c) from the mitochondria into the cytoplasm.   Mechanistically, SKF-96365 treatment inhibits the   calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling   cascade. Overexpression of CaMKIIγ or AKT abolishes the effects of SKF-96365   on cancer cells, suggesting a critical role of the CaMKIIγ/AKT signaling   pathway in SFK-96365-induced biological   effects<sup>[2]</sup>.
      
            
      
            <i><b>In Vivo:</b></i> SKF-96365 inhibits CRC cell   growth <i>in vivo</i>. SKF-96365 treatment results in a   de<br><br>
      
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            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理，營銷網(wǎng)點(diǎn)遍及全球20多個國家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商，   產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個熱門研究領(lǐng)域，PI3K、MAPK等近千個細(xì)分靶點(diǎn)，超過4000個活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時提供從毫克到千克的專業(yè)定制合成服務(wù)。</span>
      
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            已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a   href="http://www.medchemexpress.cn/skf-96365-hydrochloride.html">www.medchemexpress.cn/skf-96365-hydrochloride.html</a><br><br></span><img   style="width: 600.0px;height: 310.0px;" 
      
            
      
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