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      Nifursemizone前沿研究進展
      
                
      
                發(fā)布日期：2017-11-13                                                  瀏覽次數(shù)：0
                
      

      核心提示：Nifursemizone 是一種抗原蟲藥。BRa href=https://www.medchemexpress.cn/Aloxistatin.htmlAloxistatin/a產(chǎn)品描述：Aloxistatin
                                      
      
    
    
        
      
            Nifursemizone   是一種抗原蟲藥。<BR><a   href="https://www.medchemexpress.cn/Aloxistatin.html">Aloxistatin</a>產(chǎn)品描述：Aloxistatin   (E64d) is a broad-spectrum cell-permeable <b>cysteine   protease</b> inhibitor.IC50 & Target: Cysteine   protease<sup>[1]</sup><i><b>In   Vitro:</b></i> Inhibition of protease-resistant prion protein   (PrP-res) accumulation in ScNB cells by cysteine protease inhibitor   Aloxistatin (E64d) with IC<sub>50</sub> of 0.5±0.11 μM. For the   cell surface PrP-sen detection, PrP-sen is immunoprecipitated from media   treated with phosphatidylinositol-specific phospholipase C (PIPLC) to release   pulse-<sup>35</sup>S-labeled PrP-sen from the cell surface.   Aloxistatin is maintained at 15 μM, respectively, in the labeling media of   all but the control cells <sup>[1]</sup>. Aloxistatin (E64d)   (which specifically blocks cysteine proteases, but not serine proteases such   as granzymes) is able to completely block turnover of the CatL substrate   Z-Phe-Arg-aminomethylcoumarin, when pre-incubated with NK-92 or YT 5   cells<sup>[2]</sup>. Aloxistatin (E64d) is a broad-spectrum   cell-permeable inhibitor of cys<br><br><br><span style="outline:   0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica   Neue" , Helvetica , Arial , sans-serif;font-size:   11.818182px;background-color:   rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設有歐洲區(qū)子公司和亞洲區(qū)總代理，營銷網(wǎng)點遍及全球20多個國家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領域的一流供應商，   產(chǎn)品涵蓋癌癥、神經(jīng)科學、抗感染、表觀遺傳學等20個熱門研究領域，PI3K、MAPK等近千個細分靶點，超過4000個活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時提供從毫克到千克的專業(yè)定制合成服務。</span><br   style="color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height:   22.0px;background-color: rgb(251,251,251);"><span   style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">MCE   對每批產(chǎn)品都進行嚴格的LCMS和NMR檢驗，其產(chǎn)品已被全球近萬名客戶廣泛使用并發(fā)表大量文章、專利；</span><br   style="color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height:   22.0px;background-color: rgb(251,251,251);"><span   style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">MCE   定期增加各領域熱門抑制劑、激動劑，不斷擴增已有化合物庫，以滿足最新的科研需求；</span><br style="color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;line-height: 22.0px;background-color:   rgb(251,251,251);"><span style="outline: 0.0px;line-height:   22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">數(shù)千種產(chǎn)品在上海有充足備貨，24-48小時內(nèi)送達客戶；</span><br   style="color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height: 22.0px;background-color:   rgb(251,251,251);"><span style="outline: 0.0px;line-height:   22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">大量產(chǎn)品提供免費試用裝；</span><span   style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">已為全球多個知名企業(yè)、院校構建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a   href="http://www.medchemexpress.cn/Aloxistatin.html">www.medchemexpress.cn/Aloxistatin.html</a><br><br></span><img   style="width: 600.0px;height: 310.0px;"   src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"   alt="">Purity:98%<BR>MWt:226.1894<BR>Formula:C8H10N4O4<BR>SMILES:O=[N+](C1=CC=C(/C=N/N(C(N)=O)CC)O1)[O-]<BR>Pathway:Anti-infection;   <BR>Mechanisms:Parasite ; <BR>Research   Area:Infection<BR>電話： 021-58955995<BR>網(wǎng)址： www.MedChemExpress.cn   <BR>地址： 上海市浦東新區(qū)蔡倫路720號2號樓3層
        
      
          

      

      
                                                
       
      
                

      


      

       
      

      

      
    
    
       
      

        
      

      

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