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      YM17E前沿研究進(jìn)展
      
                
      
                發(fā)布日期：2017-11-13                                                  瀏覽次數(shù)：0
                
      

      核心提示：YM17E 是一種?；o酶a:膽固醇?；D(zhuǎn)移酶 (bACAT/b) 的抑制劑，在兔肝微粒體的體外實(shí)驗(yàn)中，bICsub50/sub/b 值為 44 nM。BRa href
                                      
      
    
    
        
      
            YM17E   是一種?；o酶a:膽固醇酰基轉(zhuǎn)移酶 (<b>ACAT</b>)   的抑制劑，在兔肝微粒體的體外實(shí)驗(yàn)中，<b>IC<sub>50</sub></b> 值為 44   nM。<BR><a   href="https://www.medchemexpress.cn/BAPTA.html">BAPTA</a>產(chǎn)品描述：BAPTA   is a specific chelator of Ca<sup>2+</sup>, suppresses   intracellular reactive oxygen species (ROS) levels.IC50 & Target:   Ca<sup>2+</sup>   chelator<sup>[1]</sup><i><b>In   Vitro:</b></i> Regarding ROS generation, a Ca<sup>2+</sup>   specific chelator, BAPTA, suppresses ROS generation of Sodium lauryl sulfate   (SLS)-exposed HaCaT keratinocytes<sup>[1]</sup>. Depolarization   does not increase the resting open probability of the mechanoelectrical   transducer (MET) current of Tmc1<sup>Bth/Bth</sup> OHCs, wheras   raising the intracellular concentration of the Ca<sup>2+</sup>   chelator BAPTA causes smaller increases in resting open probability in   Bthmutant outer hair cells (OHCs) than in wild-type control cells. In the   presence of 0.1 mM BAPTA, nonsaturating bundle displacements causes the MET   current to adapt in both genotypes, exactly as seen when 1 mM EGTA is used in   the intracellular solution. In the presence of 10 mM intracellular BAPTA, the   time-dependent MET current decline is   abolish<br><br><br><span style="outline:   0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica   Neue" , Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專(zhuān)注于各種抑制劑、激動(dòng)劑、API及化合物庫(kù)，總部位于美國(guó)新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理，營(yíng)銷(xiāo)網(wǎng)點(diǎn)遍及全球20多個(gè)國(guó)家地區(qū)。MCE經(jīng)過(guò)多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商，   產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個(gè)熱門(mén)研究領(lǐng)域，PI3K、MAPK等近千個(gè)細(xì)分靶點(diǎn)，超過(guò)4000個(gè)活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過(guò)20種不同類(lèi)型的化合物庫(kù)，同時(shí)提供從毫克到千克的專(zhuān)業(yè)定制合成服務(wù)。</span><br   style="color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height:   22.0px;background-color: rgb(251,251,251);"><span   style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">MCE 對(duì)每批產(chǎn)品都進(jìn)行嚴(yán)格的LCMS和NMR檢驗(yàn)，其產(chǎn)品已被全球近萬(wàn)名客戶廣泛使用并發(fā)表大量文章、專(zhuān)利；</span><br   style="color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height:   22.0px;background-color: rgb(251,251,251);"><span style="outline:   0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica   Neue" , Helvetica , Arial , sans-serif;font-size:   11.818182px;background-color: rgb(251,251,251);">MCE   定期增加各領(lǐng)域熱門(mén)抑制劑、激動(dòng)劑，不斷擴(kuò)增已有化合物庫(kù)，以滿足最新的科研需求；</span><br style="color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;line-height: 22.0px;background-color:   rgb(251,251,251);"><span style="outline: 0.0px;line-height:   22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">數(shù)千種產(chǎn)品在上海有充足備貨，24-48小時(shí)內(nèi)送達(dá)客戶；</span><br   style="color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height:   22.0px;background-color: rgb(251,251,251);"><span   style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">大量產(chǎn)品提供免費(fèi)試用裝；</span><span   style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫(kù)。</span><br><br>產(chǎn)品鏈接：<a   href="http://www.medchemexpress.cn/BAPTA.html">www.medchemexpress.cn/BAPTA.html</a><br><br></span><img   style="width: 600.0px;height: 310.0px;"   src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"   alt="">Purity:98%<BR>MWt:652.9116<BR>Formula:C40H56N6O2<BR>SMILES:O=C(NC1=CC=C(N(C)C)C=C1)N(CC2=CC=CC(CN(C3CCCCCC3)C(NC4=CC=C(N(C)C)C=C4)=O)=C2)C5CCCCCC5<BR>Pathway:Others;   <BR>Mechanisms:Others; <BR>Research Area:metabolic Disease<BR>電話：   021-58955995<BR>網(wǎng)址： www.MedChemExpress.cn <BR>地址：   上海市浦東新區(qū)蔡倫路720號(hào)2號(hào)樓3層
        
      
          

      

      
                                                
       
      
                

      


      

       
      

      

      
    
    
       
      

        
      

      

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