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      Sotirimod前沿研究進(jìn)展
      
                
      
                發(fā)布日期：2017-11-13                                                  瀏覽次數(shù)：0
                
      

      核心提示：Sotirimod 是一種免疫刺激劑，能夠潛在的治療光化性角化病。BRa href=https://www.medchemexpress.cn/YYA-021.htmlYYA-021/a產(chǎn)品
                                      
      
    
    
        
      
            Sotirimod   是一種免疫刺激劑，能夠潛在的治療光化性角化病。<BR><a   href="https://www.medchemexpress.cn/YYA-021.html">YYA-021</a>產(chǎn)品描述：YYA-021   is a small-molecule CD4 mimic that inhibits HIV entry, with high anti-HIV   activity and low cytotoxicity. IC50 value: 8.4 μM Target: HIVIC50 (=8.4 μM)   value of YYA-021 is determined by a single round assay using cYTA48P virus   and TZM-bl cells. YYA-021 is broadly distributed in tissues, probably as a   result of its hydrophobicity. The plasma concentrations of YYA-021 in both   species remained at micromolar levels for several hours post-injection. [1]   YYA-021 also enhances the neutralizing activity of KD-247 against   simian-human immunodeficiency virus (SHIV)-KS661 strain via highly   synergistic interactions. YYA-021 might have promise as a lead compound for   the intravenous administration in a cocktail therapy with anti-gp120   monoclonal antibodies such as KD-247 and with co-receptor antagonists such as   T140. [2]<br><br><br><span style="outline:   0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica   Neue" , Helvetica , Arial , sans-serif;font-size:   11.818182px;background-color:   rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動(dòng)劑、API及化合物庫(kù)，總部位于美國(guó)新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理，營(yíng)銷網(wǎng)點(diǎn)遍及全球20多個(gè)國(guó)家地區(qū)。MCE經(jīng)過(guò)多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商，   產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個(gè)熱門(mén)研究領(lǐng)域，PI3K、MAPK等近千個(gè)細(xì)分靶點(diǎn)，超過(guò)4000個(gè)活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過(guò)20種不同類型的化合物庫(kù)，同時(shí)提供從毫克到千克的專業(yè)定制合成服務(wù)。</span><br   style="color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height:   22.0px;background-color: rgb(251,251,251);"><span   style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">MCE   對(duì)每批產(chǎn)品都進(jìn)行嚴(yán)格的LCMS和NMR檢驗(yàn)，其產(chǎn)品已被全球近萬(wàn)名客戶廣泛使用并發(fā)表大量文章、專利；</span><br   style="color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height:   22.0px;background-color: rgb(251,251,251);"><span   style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">MCE   定期增加各領(lǐng)域熱門(mén)抑制劑、激動(dòng)劑，不斷擴(kuò)增已有化合物庫(kù)，以滿足最新的科研需求；</span><br style="color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;line-height: 22.0px;background-color:   rgb(251,251,251);"><span style="outline: 0.0px;line-height:   22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">數(shù)千種產(chǎn)品在上海有充足備貨，24-48小時(shí)內(nèi)送達(dá)客戶；</span><br   style="color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height: 22.0px;background-color:   rgb(251,251,251);"><span style="outline: 0.0px;line-height:   22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">大量產(chǎn)品提供免費(fèi)試用裝；</span><span   style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫(kù)。</span><br><br>產(chǎn)品鏈接：<a   href="http://www.medchemexpress.cn/YYA-021.html">www.medchemexpress.cn/YYA-021.html</a><br><br></span><img   style="width: 600.0px;height: 310.0px;"   src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"   alt="">Purity:98%<BR>MWt:255.3183<BR>Formula:C14H17N5<BR>SMILES:NC1=NC2=CC=CN=C2C3=C1N=C(C)N3CC(C)C<BR>Pathway:Others;   <BR>Mechanisms:Others; <BR>Research Area:Others<BR>電話：   021-58955995<BR>網(wǎng)址： www.MedChemExpress.cn <BR>地址：   上海市浦東新區(qū)蔡倫路720號(hào)2號(hào)樓3層
        
      
          

      

      
                                                
       
      
                

      


      

       
      

      

      
    
    
       
      

        
      

      

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