欧美人妻精品区三区|无码免费特级毛片|久久伊人中文无码|亚洲欧洲免费在线播放

<optgroup id="khvqs"><em id="khvqs"></em></optgroup>

    • <span id="khvqs"><sup id="khvqs"></sup></span>
      <optgroup id="khvqs"></optgroup>
      <acronym id="khvqs"><sup id="khvqs"></sup></acronym>
      <track id="khvqs"><i id="khvqs"></i></track>
    1. 






      

      
        
      
            
      
                
      
                當前位置: 首頁 » 資訊 » 行業(yè)動態(tài) » 正文
                
      

      Chidamide研究進展
      
                
      
                發(fā)布日期：2017-11-06                                                  瀏覽次數(shù)：0
                
      

      核心提示：a href=https://www.medchemexpress.com/Chidamide.htmlChidamide/a產(chǎn)品描述：Chidamide is a synthetic benzamide-type bHDACi/
                                      
      
    
    
        
      
            <a   href="https://www.medchemexpress.com/Chidamide.html">Chidamide</a>產(chǎn)品描述：Chidamide   is a synthetic benzamide-type <b>HDACi</b> which mainly acts as a   class I HDACi (inhibiting <b>HDAC1</b>, <b>HDAC2</b>,   <b>HDAC3</b> and <b>HDAC8</b> with   <b>IC<sub>50</sub></b> of 95, 160, 67 and 733 nM,   respectively).IC50 & Target: IC50: 67 nM (HDAC3), 95 nM (HDAC1), 160 nM   (HDAC2), 733 nM (HDAC8)<sup>[1]</sup><i><b>In   Vitro:</b></i> Chidamide (CS055) at low concentrations   dramatically inhibits cell proliferation in each cell line. After Chidamide   treatment, cells arrest at the   G<sub>0</sub>/G<sub>1</sub> phase in a dose-dependent   manner. Western blot analysis indicats that cyclin E1 and E2 protein   expression is down-regulated after Chidamide treatment, which is consistent   with the cell-cycle analysis. As the changes in cyclin E1 are much more   significant than cyclin E2, cyclin E1 is up-regulated in HL60 and K562 cells   by lentiviral transduction. The effect on leukaemia proliferation by   Chidamide inhibition are largely weakened when cyclin E1 is overexpressed.   It<br><br><br><span style="outline:   0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica   Neue" , Helvetica , Arial , sans-serif;font-size:   11.818182px;background-color:   rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設有歐洲區(qū)子公司和亞洲區(qū)總代理，營銷網(wǎng)點遍及全球20多個國家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領域的一流供應商，   產(chǎn)品涵蓋癌癥、神經(jīng)科學、抗感染、表觀遺傳學等20個熱門研究領域，PI3K、MAPK等近千個細分靶點，超過4000個活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時提供從毫克到千克的專業(yè)定制合成服務。</span><br   style="color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height:   22.0px;background-color: rgb(251,251,251);"><span   style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">MCE   對每批產(chǎn)品都進行嚴格的LCMS和NMR檢驗，其產(chǎn)品已被全球近萬名客戶廣泛使用并發(fā)表大量文章、專利；</span><br   style="color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height:   22.0px;background-color: rgb(251,251,251);"><span   style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">MCE   定期增加各領域熱門抑制劑、激動劑，不斷擴增已有化合物庫，以滿足最新的科研需求；</span><br style="color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;line-height: 22.0px;background-color:   rgb(251,251,251);"><span style="outline: 0.0px;line-height:   22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">數(shù)千種產(chǎn)品在上海有充足備貨，24-48小時內(nèi)送達客戶；</span><br   style="color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height:   22.0px;background-color: rgb(251,251,251);"><span   style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">大量產(chǎn)品提供免費試用裝；</span><span   style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color: rgb(251,251,251);">已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a   href="http://www.medchemexpress.cn/chidamide.html">www.medchemexpress.cn/chidamide.html</a><br><br></span><img   style="width: 600.0px;height: 310.0px;"   src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"   alt="">
        
      
          

      

      
                                                
       
      
                

      


      

       
      

      

      
    
    
       
      

        
      

      

?