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      NLG919研究進(jìn)展
      
                
      
                發(fā)布日期：2017-11-02                                                  瀏覽次數(shù)：0
                
      

      核心提示：a href=https://www.medchemexpress.com/NLG919.htmlNLG919/a產(chǎn)品描述：NLG919 is a potent bIDO/b (indoleamine-(2,3)-dioxygen
                                      
      
    
    
        
      
            <a   href="https://www.medchemexpress.com/NLG919.html">NLG919</a>產(chǎn)品描述：NLG919   is a potent <b>IDO</b> (indoleamine-(2,3)-dioxygenase) pathway   inhibitor with   <b>K<sub>i</sub></b>/<b>EC<sub>50</sub></b>   of 7 nM/75 nM. IC50 & Target: EC50: 75 nM   (IDO)<sup>[1]</sup><br/>Ki: 7 nM   (IDO)<sup>[1]</sup><i><b>In   Vitro:</b></i> Using IDO-expressing human monocyte-derived DCs in   allogeneic MLR reactions, NLG919 potently blocks IDO-induced T cell   suppression and restored robust T cell responses with an   ED<sub>50</sub>=80 nM. Similarly, using IDO-expressing mouse DCs   from tumor-draining lymph nodes, NLG919 abrogates IDO-induced suppression of   antigen-specific T cells (OT-I) in vitro, with   ED<sub>50</sub>=120   nM<sup>[1]</sup>.<i><b>In Vivo:</b></i>   NLG919 is orally bioavailable (F>70%); and has a favorable pharmacokinetic   and toxicity profile. In mice, a single oral administration of NLG919 reduces   the concentration of plasma and tissue Kyn by ~50%. In vivo, in mice bearing   large established B16F10 tumors, administration of NLG919 markedly enhances   the anti-tumor<br><br><br><span style="outline:   0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family: "Helvetica   Neue" , Helvetica , Arial , sans-serif;font-size:   11.818182px;background-color: rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理，營銷網(wǎng)點遍及全球20多個國家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商，   產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個熱門研究領(lǐng)域，PI3K、MAPK等近千個細(xì)分靶點，超過4000個活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時提供從毫克到千克的專業(yè)定制合成服務(wù)。</span><br   style="color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height:   22.0px;background-color: rgb(251,251,251);"><span   style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">MCE   對每批產(chǎn)品都進(jìn)行嚴(yán)格的LCMS和NMR檢驗，其產(chǎn)品已被全球近萬名客戶廣泛使用并發(fā)表大量文章、專利；</span><br   style="color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height:   22.0px;background-color: rgb(251,251,251);"><span   style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family:   "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size:   11.818182px;background-color: rgb(251,251,251);">MCE   定期增加各領(lǐng)域熱門抑制劑、激動劑，不斷擴增已有化合物庫，以滿足最新的科研需求；</span><br style="color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;line-height: 22.0px;background-color:   rgb(251,251,251);"><span style="outline: 0.0px;line-height:   22.0px;color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">數(shù)千種產(chǎn)品在上海有充足備貨，24-48小時內(nèi)送達(dá)客戶；</span><br   style="color: rgb(62,62,62);font-family: "Helvetica Neue" ,   Helvetica , Arial , sans-serif;font-size: 11.818182px;line-height:   22.0px;background-color: rgb(251,251,251);"><span   style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">大量產(chǎn)品提供免費試用裝；</span><span   style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a   href="http://www.medchemexpress.cn/nlg919.html">www.medchemexpress.cn/nlg919.html</a><br><br></span><img   style="width: 600.0px;height: 310.0px;"   src="http://img.dxycdn.com/trademd/upload/userfiles/image/2014/08/A1408605159png_small.jpg"   alt="">
        
      
          

      

      
                                                
       
      
                

      


      

       
      

      

      
    
    
       
      

        
      

      

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