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      ISCK03研究進(jìn)展
      
                
      
                發(fā)布日期：2017-10-30                                                  瀏覽次數(shù)：0
                
      

      核心提示：a href=https://www.medchemexpress.com/ISCK03.htmlISCK03/a產(chǎn)品描述：ISCK03 is a specific bSCF/c-Kit/b inhibitor.ibIn Vitr
                                      
      
    
    
        
      
            <a   href="https://www.medchemexpress.com/ISCK03.html">ISCK03</a>產(chǎn)品描述：ISCK03   is a specific <b>SCF/c-Kit</b> inhibitor.
      
            
      
            <i><b>In Vitro:</b></i> Pretreatment of 501mel   cells with ISCK03 inhibits SCF-induced c-kit phosphorylation dose   dependently. ISCK03 also inhibits p44/42 ERK mitogen-activated protein kinase   (MAPK) phosphorylation, which is known to be involved in SCF/c-kit downstream   signaling. However ISCK03 does not inhibit hepatocyte growth factor   (HGF)-induced phosphorylation of p44/42 ERK   proteins<sup>[1]</sup>. ISCK03, a tyrosine kinase inhibitor   specific to KIT, prevents survival of CCDC26-KD cells under low-serum   conditions. All treated cells exhibits sensitivity to ISCK03 in a   dose-dependent manner. After ISCK03 treatment, the survival of KD cells is   suppressed to the same level as that of non-KD cells. Conversely, ISCK03   treatment has limited effects on the growth of control K562 and KD clone 3–4   cells under high-serum concentration   conditions<sup>[2]</sup>.
      
            
      
            <i><b>In Vivo:</b></i> Oral administration of   ISCK03 induces the dose-dependent dep<br><br>
      
            <br>
      
            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動(dòng)劑、API及化合物庫(kù)，總部位于美國(guó)新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理，營(yíng)銷網(wǎng)點(diǎn)遍及全球20多個(gè)國(guó)家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商，   產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個(gè)熱門研究領(lǐng)域，PI3K、MAPK等近千個(gè)細(xì)分靶點(diǎn)，超過4000個(gè)活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫(kù)，同時(shí)提供從毫克到千克的專業(yè)定制合成服務(wù)。</span>
      
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            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">大量產(chǎn)品提供免費(fèi)試用裝；</span>
      
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            已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫(kù)。</span><br><br>產(chǎn)品鏈接：<a   href="http://www.medchemexpress.cn/isck03.html">www.medchemexpress.cn/isck03.html</a><br><br></span><img   style="width: 600.0px;height: 310.0px;" 
      
            
      
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