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      Z-IETD-FMK研究進展
      
                
      
                發(fā)布日期：2017-10-30                                                  瀏覽次數(shù)：0
                
      

      核心提示：a href=https://www.medchemexpress.com/Z-IETD-FMK.htmlZ-IETD-FMK/a產(chǎn)品描述：Z-IETD-FMK is a selective and cell permeable
                                      
      
    
    
        
      
            <a   href="https://www.medchemexpress.com/Z-IETD-FMK.html">Z-IETD-FMK</a>產(chǎn)品描述：Z-IETD-FMK   is a selective and cell permeable <b>caspase 8</b>   inhibitor.
      
            
      
            <i><b>In Vitro:</b></i> Z-IETD-FMK causes full   inhibition only of the proapoptotic effect of TNFα with an   IC<sub>50</sub> of 0.46 μM<sup>[1]</sup>. Z-IETD-FMK   and Z-VAD-FMK at non-toxic doses are found to be immunosuppressive and   inhibit human T cell proliferation induced by mitogens and IL-2. They are   shown to block NF-κB in activated primary T cells, but have little inhibitory   effect on the secretion of IL-2 and IFN-γ during T cell   activation<sup>[2]</sup>. Z-IETD-FMK inhibits the cleavage of   caspase-8 and only partially inhibits the cleavage of caspase-3 and PARP.   Z-IETD-FMK can prevent the execution of apoptosis in retinal cells exposed to   different apoptotic stimuli<sup>[3]</sup>.
      
            
      
            <i><b>In Vivo:</b></i> Pharmacological inhibition   of caspase-8 by z-IETD-FMK robustly reduces tumour outgrowth and this is   closely associated with a reduction in the release of pro-inflammatory   cytokines, IL-6, TNF-α, IL-18, IL-1<br><br>
      
            <br>
      
            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理，營銷網(wǎng)點遍及全球20多個國家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商，   產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個熱門研究領(lǐng)域，PI3K、MAPK等近千個細(xì)分靶點，超過4000個活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時提供從毫克到千克的專業(yè)定制合成服務(wù)。</span>
      
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            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">大量產(chǎn)品提供免費試用裝；</span>
      
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            已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a   href="http://www.medchemexpress.cn/z-ietd-fmk.html">www.medchemexpress.cn/z-ietd-fmk.html</a><br><br></span><img   style="width: 600.0px;height: 310.0px;" 
      
            
      
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