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      WAY-200070研究進展
      
                
      
                發(fā)布日期：2017-10-27                                                  瀏覽次數(shù)：0
                
      

      核心提示：a href=https://www.medchemexpress.com/WAY-200070.htmlWAY-200070/a產(chǎn)品描述：WAY-200070 is a selective estrogen receptor(b
                                      
      
    
    
        
      
            <a   href="https://www.medchemexpress.com/WAY-200070.html">WAY-200070</a>產(chǎn)品描述：WAY-200070   is a selective estrogen receptor β (<b>ERRβ</b>) agonist with an   <b>IC<sub>50</sub></b> of 2.3 nM.
      
            
      
            IC50 & Target: IC50: 2.3 nM (ERRβ), 155 nM   (ERRα)<sup>[1]</sup>
      
            
      
            <i><b>In Vivo:</b></i> Administration of WAY-200070   (30 mg/kg s.c.) causes nuclear translocation of ERRβ receptors in WT mice. Administration   of WAY-200070 (30 mg/kg s.c.) produces a delayed 50% increase in dopamine in   the striatum of wild type mice. WAY-200070 (30 mg/kg s.c.) reduces immobility   time in the mouse tail suspension test indicating an antidepressant-like   effect<sup>[1]</sup>. In gonadally intact male and female mice   WAY-200070 increases agonistic behaviors such as pushing down and aggressive   grooming, while leaving attacks unaffected<sup>[2]</sup>.   Ovariectomized (ovx) mice treated with PPT fail to learn the socially   acquired preference, while WAY-200070-treated ovx mice shows a two-fold   prolonged preference for the food eaten by their   demonstrator<sup>[3]</sup>. WAY-200070, shows significantly   decr<br><br>
      
            <br>
      
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            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">大量產(chǎn)品提供免費試用裝；</span>
      
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            已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a   href="http://www.medchemexpress.cn/way-200070.html">www.medchemexpress.cn/way-200070.html</a><br><br></span><img   style="width: 600.0px;height: 310.0px;" 
      
            
      
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