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      Silodosin研究進展
      
                
      
                發(fā)布日期：2017-10-27                                                  瀏覽次數(shù)：0
                
      

      核心提示：a href=https://www.medchemexpress.com/Silodosin.htmlSilodosin/a產(chǎn)品描述：Silodosin (Rapaflo; KMD-3213) is an 1-adrenocep
                                      
      
    
    
        
      
            <a   href="https://www.medchemexpress.com/Silodosin.html">Silodosin</a>產(chǎn)品描述：Silodosin   (Rapaflo; KMD-3213) is an α1-adrenoceptor antagonist with high   uroselectivity; In treatment of dysuria.
      
            
      
            IC50 Value:
      
            
      
            Target: Adrenergic Receptor
      
            
      
            in vitro: Silodosin potently inhibited   2-[2-(4-hydroxy-3-[125I]iodophenyl)ethylaminomethyl]-alpha-tetralone binding   to the cloned human alpha 1a-AR, with a Ki value of 0.036 nM, but had 583-   and 56-fold lower potency at the alpha 1b- and alpha 1d-ARs, respectively.   Silodosin inhibited norepinephrine-induced increases in intracellular Ca2+   concentrations in alpha 1a-AR-expressing Chinese hamster ovary cells with an   IC50 of 0.32 nM but had a much weaker inhibitory effect on the alpha 1b- and   alpha 1d-ARs.
      
            
      
            in vivo: Using pharmacologically well characterized native rat tissues   [submaxillary gland (alpha 1A-AR-expressing tissue), liver (alpha   1B-AR-expressing tissue), and heart (mixed alpha 1A- and alpha   1B-AR-expressing tissue)], binding studies showed that inhibition curves for   Silodosin in submaxillary gland and liver best fit a   on<br><br>
      
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            <span style="outline: 0.0px;line-height: 22.0px;color: rgb(62,62,62);font-family:   "Helvetica Neue" , Helvetica , Arial , sans-serif;font-size:   11.818182px;background-color:   rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設有歐洲區(qū)子公司和亞洲區(qū)總代理，營銷網(wǎng)點遍及全球20多個國家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領域的一流供應商，   產(chǎn)品涵蓋癌癥、神經(jīng)科學、抗感染、表觀遺傳學等20個熱門研究領域，PI3K、MAPK等近千個細分靶點，超過4000個活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時提供從毫克到千克的專業(yè)定制合成服務。</span>
      
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            已為全球多個知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a   href="http://www.medchemexpress.cn/silodosin.html">www.medchemexpress.cn/silodosin.html</a><br><br></span><img   style="width: 600.0px;height: 310.0px;" 
      
            
      
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