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      TB5研究進(jìn)展
      
                
      
                發(fā)布日期：2017-10-27                                                  瀏覽次數(shù)：0
                
      

      核心提示：a href=https://www.medchemexpress.com/TB5.htmlTB5/a產(chǎn)品描述：TB5 is a potent, selective and reversible inhibitor of bhMA
                                      
      
    
    
        
      
            <a   href="https://www.medchemexpress.com/TB5.html">TB5</a>產(chǎn)品描述：TB5   is a potent, selective and reversible inhibitor of <b>hMAO-B</b>   with a <b>K<sub>i</sub></b> value of 0.11±0.01   μM.
      
            
      
            IC50 & Target: Ki: 0.11±0.01 μM   (hMAO-B)<sup>[1]</sup>
      
            
      
            <i><b>In Vitro:</b></i> TB5 and TB8 interacts with   the catalytic site of hMAO-B and hMAO-A with a competitive mode of   inhibition. TB5 shows the best inhibitory activity and higher selectivity   toward hMAO-B, with K<sub>i</sub> and SI values of 0.11±0.01μM   and 13.18, respectively. hMAO-B inhibition by compound TB5 and hMAO-A   inhibition by compound TB8 are completely reversed after 24 h of dialysis.   Cytotoxicity studies show TB5 is nontoxic at 5 and 25 μM, resulting in cell   viabilities of 95.75% and 84.59 %,   respectively<sup>[1]</sup>.
      
            
      
            <i><b>In Vivo:</b></i> Compounds are dissolved in   DMSO (5 mg/mL) and diluted with PBS/EtOH (70:30).Kinetic analyses are carried   out for TB5 and TB8. A set of Lineweaver–Burk plots are constructed in the   absence and presence of various concentrations of compounds TB5 and TC8. The   se<br><br>
      
            <br>
      
            <span style="outline: 0.0px;line-height: 22.0px;color:   rgb(62,62,62);font-family: "Helvetica Neue" , Helvetica , Arial ,   sans-serif;font-size: 11.818182px;background-color:   rgb(251,251,251);">公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動(dòng)劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理，營銷網(wǎng)點(diǎn)遍及全球20多個(gè)國家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商，   產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個(gè)熱門研究領(lǐng)域，PI3K、MAPK等近千個(gè)細(xì)分靶點(diǎn)，超過4000個(gè)活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時(shí)提供從毫克到千克的專業(yè)定制合成服務(wù)。</span>
      
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            已為全球多個(gè)知名企業(yè)、院校構(gòu)建各種定制型化合物庫。</span><br><br>產(chǎn)品鏈接：<a   href="http://www.medchemexpress.cn/tb5.html">www.medchemexpress.cn/tb5.html</a><br><br></span><img   style="width: 600.0px;height: 310.0px;" 
      
            
      
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