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      Lodoxamide研究進(jìn)展
      
                
      
                發(fā)布日期：2017-11-02                                                  瀏覽次數(shù)：1
                
      

      核心提示：a href=https://www.medchemexpress.com/Lodoxamide.htmlLodoxamide/a產(chǎn)品描述：Lodoxamide is an antiallergic compound acting
                                      
      
    
    
        
      
            Lodoxamide產(chǎn)品描述：Lodoxamide   is an antiallergic compound acting as a mast-cell stabilizer for the   treatment of asthma and allergic conjunctivitis.In Vitro:   Lodoxamide inhibits compound 48/80-induced histamine release and   ionophore-induced 45Ca influx with associated   histamine release in purified rat peritoneal mast   cells[1]. The chemotactic response of eosinophils to   fMLP as well as to IL-5 is significant and dose-dependent inhibited by   Lodoxamide. Lodoxamide is also able to strongly inhibit the release of   eosinophil peroxidase after IgA-dependent activation and, to a lesser extent,   the release of eosinophil cationic protein and eosinophil-derived   neurotoxin[2]. In   Vivo: Lodoxamide has been demonstrated to have   cromolyn-like activity when studied in the rat peritoneal mast cell assay   (PCA) model3 and in Ascaris antigen-sensitized rhesus monkeys. When given   intravenously, orally, or intrabronchially by aerosol, lodoxamide   significantly inh
      
            
      
            
      
            公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設(shè)有歐洲區(qū)子公司和亞洲區(qū)總代理，營銷網(wǎng)點(diǎn)遍及全球20多個國家地區(qū)。MCE經(jīng)過多年努力已成為全球生物活性小分子領(lǐng)域的一流供應(yīng)商，   產(chǎn)品涵蓋癌癥、神經(jīng)科學(xué)、抗感染、表觀遺傳學(xué)等20個熱門研究領(lǐng)域，PI3K、MAPK等近千個細(xì)分靶點(diǎn)，超過4000個活性小分子化合物現(xiàn)貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時提供從毫克到千克的專業(yè)定制合成服務(wù)。
      
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            產(chǎn)品鏈接：www.medchemexpress.cn/lodoxamide.html
      
            
      
                  		
        
      
          

      

      
                                                
       
      
                


       
      

      

      
    
    
       
      

        
      

      

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