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      Banoxantrone (dihydrochloride
      
                
      
                發(fā)布日期：2017-11-02                                                  瀏覽次數(shù)：0
                
      

      核心提示：a href=https://www.medchemexpress.com/Banoxantrone_dihydrochloride.htmlBanoxantrone (dihydrochloride)/a產品描述：Banoxan
                                      
      
    
    
        
      
            Banoxantrone   (dihydrochloride)產品描述：Banoxantrone dihydrochloride is a novel   bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4,   which is a potent topoisomerase II   inhibitor.In Vitro: Banoxantrone (AQ4N)   can be reduced in a hypoxic environment to a stable DNA-affinic agent AQ4.   AQ4, a potent topoisomerase II inhibitor, would be capable of damaging cells   recruited into the cell cycle following radiation damage to the   well-oxygenated cells of the tumor[1]. Banoxantrone   shows more than 8-fold higher cytotoxicity under hypoxia than normoxia in   cultures of 9L rat gliosarcoma and H460 human non-small-cell lung carcinoma   cells but not for 11 other human cancer cell lines. DT-diaphorase protein   levels and banoxantrone chemosensitivity are poorly correlated across the   cancer cell line panel, and banoxantrone chemosensitivity is not affected by   DT-diaphorase inhibitors[2].  Banoxantrone is a bis-N-oxide that is   reduced via two sequential two-electron   reduct
      
            
      
            
      
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            產品鏈接：www.medchemexpress.cn/banoxantrone-dihydrochloride.html
      
            
      
                  		
        
      
          

      

      
                                                
       
      
                


       
      

      

      
    
    
       
      

        
      

      

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