| Gemcitabine (elaidate)產品描述：Gemcitabine elaidate(CP-4126; CO-101) is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity.IC50 value:Target: Gemcitabine analogUpon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Due to its lipophilicity, gemcitabine 5'-elaidic acid ester exhibits an increased cellular uptake and accumulation, resulting in an increased conversion to active metabolites, compared to gemcitabine. In addition, this formulation of gemcitabine may be less susceptible to deamination and deactivation by deoxycytidine deaminase. Check for active clinical 公司介紹：MedChemExpress(MCE)專注于各種抑制劑、激動劑、API及化合物庫，總部位于美國新澤西，分別在瑞典和上海設有歐洲區(qū)子公司和亞洲區(qū)總代理，營銷網點遍及全球20多個國家地區(qū)。MCE經過多年努力已成為全球生物活性小分子領域的一流供應商， 產品涵蓋癌癥、神經科學、抗感染、表觀遺傳學等20個熱門研究領域，PI3K、MAPK等近千個細分靶點，超過4000個活性小分子化合物現貨，以及GPCR、API、離子通道等超過20種不同類型的化合物庫，同時提供從毫克到千克的專業(yè)定制合成服務。 MCE 對每批產品都進行嚴格的LCMS和NMR檢驗，其產品已被全球近萬名客戶廣泛使用并發(fā)表大量文章、專利； MCE 定期增加各領域熱門抑制劑、激動劑，不斷擴增已有化合物庫，以滿足最新的科研需求； 數千種產品在上海有充足備貨，24-48小時內送達客戶； 大量產品提供免費試用裝；已為全球多個知名企業(yè)、院校構建各種定制型化合物庫。 產品鏈接：www.medchemexpress.cn/gemcitabine-elaidate.html  |
Gemcitabine (elaidate)研究進展
發(fā)布日期：2017-11-02 瀏覽次數：0
核心提示：a href=https://www.medchemexpress.com/Gemcitabine-elaidate.htmlGemcitabine (elaidate)/a產品描述：Gemcitabine elaidate(CP
行業(yè)動態(tài)
更多...
- ATN-161 (trifluoroacetat 11-06
- AZM475271研究進展 11-06
- AVN-944研究進展 11-06
- Ascomycin研究進展 11-06
- β-Lapachone研究進展 11-06
- Anidulafungin研究進展 11-06
- Amsacrine (hydrochloride 11-06
- Amsacrine研究進展 11-06
- Uramustine研究進展 11-06
- Exherin (trifluoroacetat 11-06
110102000668（1）號